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KMID : 1039420220560010053
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Journal of Pathology and Translational Medicine
2022 Volume.56 No. 1 p.53 ~ p.56
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TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
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Mehta Anurag
Diwan Himanshi
Bansal Divya
Gupta Manoj
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Abstract
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SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non?small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.
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KEYWORD
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BRG1, Lung, Non-small cell lung carcinoma, SMARCA4, Thyroid transcription factor 1
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